New PDF release: Amino Acids, Peptides and Proteins (SPR Amino Acids,

By John S. Davies

ISBN-10: 0854042520

ISBN-13: 9780854042524

Fundamental reference resource for researchers within the pharmaceutical and allied industries, and on the biology/chemistry interface in academia. summary: integral reference resource for researchers within the pharmaceutical and allied industries, and on the biology/chemistry interface in academia. learn more...

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Extra info for Amino Acids, Peptides and Proteins (SPR Amino Acids, Peptides, and Proteins (RSC)) (Vol 36)

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175 Diastereoselective conjugate addition of lithium (S)-N-allyl-N-a-methylbenzylamide to a range of a,b-unsaturated esters followed by ring closing metathesis was used to afford efficiently a range of substituted cyclic b-amino esters. 15 Resolution of amino acids (Enantioseparation) Separation of chiral intermediates is of tremendous importance in a number of fields. As new single stereoisomer drugs are developed in the pharmaceutical industry, the need for new chiral separation methods increases.

90 Convenient asymmetric91 and solid-phase92 syntheses of a,a-difluoro-b-amino acids were carried out by Reformatsky reaction. 5 Aliphatic and cycloaliphatic a-amino acids Cyclic amino acids such as carboxycyclopropylglycines have attracted interest due to their remarkable biological activity. They can be regarded as conformationally fixed analogues of Glu. It has been shown that these amino acids can interact very strongly and selectively with the metabotropic glutamate receptors in the mammalian central nervous systems.

This reactivity is thought to be one of the molecular mechanisms underlying the biological activities of dehydropeptides. A selective synthesis of Z- and E-DAbu from L- and L-allo-Thr as starting materials through selenation and oxidative elimination processes with a selenyl linker has been described (Scheme 23). 105 Scheme 23 o-Unsaturated amino acids are of value in terms of their biological importance and their utility as asymmetric synthetic building blocks. The double bond is a masked functional group, and is stable to most acidic and basic reaction conditions.

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Amino Acids, Peptides and Proteins (SPR Amino Acids, Peptides, and Proteins (RSC)) (Vol 36) by John S. Davies


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